The new coronavirus strain carrying the d614g mutation was recently isolated from four patients with two cluster infections in Malaysia, Nur Hisham, director of the Ministry of health of Malaysia, said in a social media article recently that the new coronavirus strain carrying the d614g mutation was “10 times more infectious”.
as for the expansion of the transmission range of the mutant strain, the public is worried about whether it is more dangerous to carry the new coronavirus strain named d614g mutation? Will it affect the development of new coronal vaccine?
NCV belongs to RNA (RNA) virus and mutates relatively quickly. University College London researchers reported in the journal infection, genetics and evolution in early May that they had identified 198 repeated mutations in the genome of the new coronavirus, which shared the same ancestor from the end of 2019.
in fact, d614g is not a new mutation, which has been isolated and identified in the early stage of the epidemic. In early July, Maria van Kirchhoff, who’s head of new coronavirus technology, reported that the mutant strain had been identified as early as February this year, when it spread mainly in Europe and America.
in a study published in the International Journal of infectious diseases in May, researchers analyzed the “phylogenetic tree” of a new coronavirus containing more than 4000 viral genomes, and found that infection with a d614g mutation may be associated with a higher mortality rate.
the researchers observed that one of the characteristics of the new coronavirus strains that may cause fatal infections in European populations is the d614g mutation. But the researchers also stressed that the study lacked experimental evidence and was only an analysis of limited data.
in another study published online in the US journal Cell in early July, researchers from Los Alamos National Laboratory and other institutions reported that the strain carrying the d614g mutation has become one of the most common strains in the world’s new epidemic. From the perspective of different geographical areas, such as countries, regions and cities, compared with the strains without d614g mutation, they carry the mutation The infection rate of d614g strains increased periodically, which indicated that d614g mutation had more advantages in adaptability.
van Kirchhoff also stressed that up to now, there is no evidence that the strain carrying the d614g mutation will lead to more serious diseases. It is generally believed that more research is needed to determine whether d614g mutation will have a significant impact on the transmission speed and pathogenicity of the new coronavirus.
according to the existing research results, some experts believe that d614g mutation is not likely to have a significant impact on the efficacy of the new crown vaccine under study.
most of the new coronavirus vaccines under study take the receptor binding domain (RBD) of the spike protein of the new coronavirus as the target. By expressing the RBD, the human immune system can produce neutralizing antibodies that can bind to the new coronavirus, so as to achieve the goal of preventing infection. However, d614g mutation is not in RBD, so it is unlikely to affect the ability of RBD expressing vaccine to induce human immune response.