From January 1, 2015 to June 1, 2020, the University of North Carolina at Chapel Hill (UC) reported 28 laboratory incidents involving “genetically engineered organisms” to National Institutes of Health (NIH) safety officials from January 1, 2015 to June 1, 2020. The viruses were engineered to be tested in mice. < p > < p > what is more shocking is that all the six accidents of artificial coronavirus occurred in the “heavily guarded” Biosafety Level 3 (BSL-3) laboratory, and one of them was related to the research of new coronavirus. Propublica said that the UNCC declined to answer other questions related to the accident and to disclose key details such as the specific name of the virus, the nature of the virus modification and the risk to the public. < / P > < p > in August 2015, an infected mouse broke free from the researchers’ gloved hands, ran to the laboratory floor, was caught and put back into the cage. NIH said the accident involved a “SARS related coronavirus.”. Although the researchers were all wearing protective equipment, the accident was still considered a “potential exposure” and the two researchers were required to undergo 10 days of medical surveillance, reporting body temperature and symptoms twice a day. < / P > < p > in October 2015, a culture dish containing SARS related coronavirus that can infect mice fell to the floor and overturned, possibly producing “suspension droplets”. Although all three researchers in the laboratory were wearing safety equipment and electric air purification respirators at the time, the school’s safety officials thought it was a “potential exposure” and the staff received 10 days of medical care. < / P > < p > in November 2015, in the process of transferring infected mice to clean cages, laboratory researchers knocked over contaminated dirty cages. The virus in the accident was a modified Middle East respiratory syndrome (mers) virus. The two staff members were forced to leave, let the suspended particles from the accident settle on the ground, and then return to clean up the area. They also received 10 days of medical care. < / P > < p > in February 2016, researchers were bitten through two layers of gloves and bit their fingers while weighing a mouse. The accident also involved SARS related coronavirus. According to the procedure, the staff involved disinfected the gloves, let the wound bleed for one minute, and then washed it with soap and water for five minutes. After the accident, the relevant personnel were not isolated and were only required to wear masks in public places and at work, and report body temperature and symptoms twice a day. Because the virus is on the list of dangerous pathogens regulated by the U.S. federal government, the incident was reported to the Centers for Disease Control and prevention. < / P > < p > in April 2017, a plate containing an infected mouse lung sample fell from the researcher’s hands, causing the door and floor of the incubator to be contaminated with a small amount of viral material. NIH said the virus in the accident was also a SARS related coronavirus. The occupational health clinic of the school staff said that due to the small amount of leakage and the intact protective equipment, the three researchers in the laboratory did not need to report their body temperature to the clinic. They only needed to do daily self-monitoring to pay attention to respiratory symptoms and temperature changes. < / P > < p > in April 2020, a researcher was reading the identification number on a label on a mouse’s ear when the mouse turned over and bit through its two layers of protective gloves. By this time the mice had been infected with a branch of the new coronavirus. Although the researcher’s skin “does not appear to have been punctured”, the UNCC still regarded it as a “medium and high-risk exposure” and informed the local health department that the staff involved were required to undergo self isolation at home for 14 days and check their temperature twice a day. < / P > < p > although, according to independent science news, the UNCC replied that the aim of the experiment in April this year was to develop a mouse model for preclinical drug trials, and the accident did not lead to infection. But the accident is enough to ring a biological safety alarm for the explosive growth of new coronavirus research. According to Edward Hammond, former director of sunshine project, a non-governmental organization that tracks the expansion of us biological defense program after the September 11 incident, Edward Hammond said, “we need to keep a clear mind on the risks”. The modified new coronavirus may infect researchers, especially inexperienced researchers, and lead to very dangerous and unpredictable results. The greatest risk is the production and accidental release of a new coronavirus, which could undermine global efforts to stop a pandemic by developing new coronavirus vaccines and treatments. Richard ebrait, an epidemiologist at Rutgers University, said that at present, almost every BSL-3 laboratory in the world is carrying out research on infectious new coronavirus, and researchers lacking the same level of laboratory operation and pathogen research experience will increase the risk of pathogen accidents in BSL-3 laboratory. It is extremely irresponsible and absolutely unacceptable to carry out virus culture and virus production research with new coronavirus with “complete infectivity” in BSL-2 laboratory.