In the middle ages, a terrible disease suddenly spread among European countries: patients experienced strange illusions, resulting in incapacity, or gradually collapsing hands and feet until the limbs were necrotic and disabled. Serious illness brought about the patient with burning pain like fire, which was thought to be the punishment of the gods, called the “holy fire” (or “the fire of Saint Anthony”). The main cause of this disease is Claviceps fungi. It will sneak into the ovary of Gramineae such as wheat, grow into a poisonous grain of “cornmeal”, mix it into wheat grains, and finally grind it into flour and be eaten by people. It is found that the wheat horn contains alkaloids, some of which act on the nervous system, causing serious hallucinations and mental disorders, and also on the circulatory system, which causes the blood vessels of limbs to contract, and lead to the loss of blood supply and necrosis of the limbs. The so-called “fire of San Antonio” is actually severe ergot poisoning. Fortunately, with the development of agricultural technology, the poisoning of wheat horn has rarely occurred. However, McGonagall did not quit human life, but was reactivated in a different way. In recent years, people have isolated the active alkaloids from corncob one by one, and then applied them to medical treatment after purification or transformation. For example, ergonoxine can promote uterine contraction, and can treat postpartum hemorrhage; ergometamin, used for severe migraine; synthetic carbendrin and bromocriptine are good drugs for Parkinson’s disease In some parts of the United States, Heloderma suspectum is a kind of creature that people can not avoid. It secretes venom in saliva of mandible. Once bitten, it will cause severe pain, nausea and vomiting, and even severe pancreatitis. But in this lizard, scientists have discovered a new type of drug that can not only help diabetic patients control blood sugar, but also can be used to treat obesity. In the 1990s, young researchers johneng began to study saliva secreted by the lizard and tried to find useful compounds from them. It was found that a substance in the saliva of the Shiraz lizard can reduce the blood glucose of the experimental rats. After careful study, he found that the substance had the same effect as that of glucagon like peptide-1, a known hypoglycemic hormone in the human body. As early as more than ten years ago, scientists realized the hypoglycemic effect of GLP-1, which can automatically regulate the rate of insulin secretion according to the current blood glucose concentration of human body. Unfortunately, GLP-1 hormone produced naturally in the human body is very fragile, and it will be degraded and ineffective after injection into the human body, which makes it unsuitable for drug production. It is not easy to degrade in vivo: it can be kept for a long time. Further clinical trials have shown that the drug can effectively help diabetic patients control blood sugar by injecting twice a day, and the effect is no less than oral hypoglycemic. Based on the significant results of large clinical trials, the drug, Byetta, was approved by the FDA in 2005. After isenatin was launched, many other GLP-1 hormone like drugs have been introduced into clinical practice, including lilaruptin, which has set billions of dollars of annual sales record, which is not only used for diabetes, but also approved for auxiliary treatment of obesity in 2014, which can effectively reduce weight and reduce obesity complications. As an ancient medicinal plant, Datura was born with poison and Shenyao. Humans have long begun to use Mandala to treat disease or to deal with enemies. From the compendiumofmateriamedica of the original grass to the “Water Margin”, there are Mandala figures. After the establishment of modern medicine, the role of “poison” of Mandala gradually faded out, and the principle of anesthesia was thoroughly revealed: Mandala contains a chemical called scopolamine, which can interfere with the function of acetylcholine, an important messenger of human nervous system, which leads to confusion of consciousness, muscle relaxation, sweat loss, and gastrointestinal peristalsis slowing down Yes. The medical value of some alkaloids (especially scopolamine and atropine) in Datura has been discovered, and they are now used to treat a variety of diseases. For example, scopolamine has been used for a long time to treat intestinal dysfunction, visceral spasm, carsickness and seasickness, etc., and atropine has become an important medicine to rescue pesticide poisoning, fatal bradycardia and other life-threatening situations. In the rescue cart of modern hospital, one position is left for atropine. Since ancient times, we have never lacked the figure of various poisons, which once took the health and life of countless people. Nowadays, many poisons which were originally feared to avoid are given a new way of opening up by pharmacists. Shaking body has become a good medicine for saving lives and supporting injuries, leaving a heavy color in human history.