This dangerous substance is 2,4-dinitrophenol, also known as DNP. Many of the so-called fast fat burning drugs and fitness drugs illegally sold on the Internet contain DNP. < p > < p > DNP does burn fat, but it can also kill people. There is no safe dose at all. Some people who take DNP will go up in a few hours. How can such a powerful poison become a slimming drug? < / P > < p > the direct energy of cells comes from ATP, which is produced in mitochondria, the power station of cells, which is taught by middle school biology. However, DNP can block the conversion of energy into ATP, and at the same time convert that energy into heat. In order to produce the same amount of ATP, mitochondria have to increase horsepower and consume more energy, which is the principle of DNP weight loss. < p > < p > specifically, in mitochondria, the ATP synthesis factory (ATP synthase) is similar to a water wheel, which rotates to drive ATP synthesis. The energy of this water wheel rotation comes from the difference of proton (H +) concentration on both sides of mitochondrial membrane. As long as there are more protons outside, there will be an endless stream of “water” pushing the water wheel to synthesize ATP. However, DNP can cut off the flow of water and stop the water wheel, resulting in ATP synthesis failure. < p > < p > after taking 100 mg of DNP, the metabolic rate of human body increased by 11%. Most of the energy that should have been used to synthesize ATP is converted into heat, which raises the body temperature. Russian soldiers took DNP to keep warm during World War II because of the side effects of heat production. It’s a fighting race. < p > < p > therefore, oral DNP can make the body quickly consume fat and carbohydrate, so as to achieve the effect of rapid weight loss. Then, in the United States, DNP was introduced into the market as an over-the-counter weight-loss drug, one of which was called formula 281. < p > < p > because of its immediate effect, DNP soon gained the reputation of “king of weight loss drugs”, and consumers scrambled to buy it. Within a year of the advent of DNP, at least 100000 Americans used it to lose weight. < / P > < p > in the literature, the average time to die of overdose of DNP is 14 hours, and the earliest acute symptoms, such as sweating, appear three and a half hours after taking DNP; the minimum lethal dose is 4.3 mg / kg body weight. What’s worse, DNP has no antidote. Many people who have been taking DNP for a long time suffer from damage to important organs and cataracts. < / P > < p > in fact, during World War I, workers in French military factories lost weight after exposure to high concentrations of DNP. Hundreds of workers were poisoned and 63 died. In March, a report by the high court of England and Wales even compared cyanide to the toxicity of DNP. < p > < p > DNP is a kind of nitrophenol compounds, which can easily be converted into nitroso which can cause hypoxia in tissues and hydroxylamine derivatives. Because it is difficult to be degraded by aerobic microorganisms in the environment, DNP has been listed in the “priority control pollutants list” by the United States Environmental Protection Agency. < p > < p > in short, DNP’s life as a legitimate weight loss drug was quickly terminated. In 1938, the U.S. Food and Drug Administration (FDA) labeled it “extremely dangerous, not suitable for human consumption.”. Later, Canada and many European countries also banned the drug. < p > < p > in 1981, a doctor named bachynsky made DNP into tablets and sold them under mitcal’s trademark. After being warned by various investigations, the man continued his DNP diet business and ended up in prison in 2008. However, it was not until 2003 that the Food Standards Agency labeled DNP “unfit for human consumption” because too many fitness and rail enthusiasts have taken DNP in recent years. It was not illegal to hold or sell DNP in the UK, because DNP was also used to make explosives, fertilizers, pesticides and dyes. Therefore, some illegal vendors sell DNP under these legal names to people who want to lose weight and keep fit. < / P > < p > selling DNP online is also a lucrative business. In China and India, DNP purchased in the name of fertilizer and so on costs about 14 pounds per kilogram, but when it is made into pills, its price can rise 100 times. In 2015, the International Criminal Police Organization (Interpol) issued a global health warning on DNP, warning people not to buy magic weight-loss pills containing DNP. In the operation between May and June 2016, FDA, in conjunction with the U.S. Customs and border protection, closed 4402 websites suspected of selling illegal drugs such as DNP. < / P > < p > although it is impossible to search for the same product with DNP on large-scale e-commerce platforms at home and abroad, a large number of DNP sellers can be found in Google. Driven by interests, DNP’s business continues in the dark corner of the Internet. Children in adolescence are very sensitive to their appearance. Parents must pay attention to suspicious yellow drugs with the words “fast burning fat” and unknown ingredients. These are the former names of DNP: dinosan, DNOC, solfo black, nitrophen, aldifen, chemox. < / P > < p > in the laboratory, DNP is often used as a research line year. In a study published in science by Shulman’s team, it was found that DNP has reduced toxicity after being modified and has the potential to treat fatty liver. Hope that the transformed DNP can become a real cure one day.