The day before yesterday, my cousin called me and asked, “do you want HPV vaccine? It seems that many people are fighting around. Should I join in the fun? After a few years, it will be too late to be old. ” As a vaccine against cervical cancer, HPV vaccine has become more and more popular in recent years. In many cities, the appointment line for cervical cancer vaccine is scheduled for next year. However, since the launch of HPV vaccine, various questions have emerged in endlessly. Today, Professor Wei Lihui, from the people’s Hospital of Peking University, answered the frequently asked questions about HPV vaccine at the 4th Oriental obstetrics and Gynecology forum. < p > < p > at the beginning, most of the women infected with HPV were asymptomatic transient infection, which may be clinically manifested as low-grade squamous intraepithelial lesion (LSIL). When we have good immunity, the possibility of virus being cleared by the body’s own immunity is higher than 80%. However, if the infection continues, it will develop into high-grade squamous intraepithelial lesion (HSIL). Usually, if persistent infection, after 10-20 years will evolve into cervical cancer! Data show that 70% – 80% of Chinese women have been infected with HPV at least once in their lifetime. HPV infection usually occurs 2.6 months after women’s first sexual life, and about 60% of women are found HPV infection within the next five years. < p > < p > in China, 73% of high-risk HPV positive women were infected with one high-risk HPV type, and less than 10% were infected with three or more high-risk HPV types. There were two peaks of infection in women of different age groups, the low age group was 17-24 years old, and the high age group was 40-44 years old. In particular, women in the lower age group need to be particularly protected against HPV. According to the data, about 30.6% of Chinese women aged 15-19 years were infected with HPV after their first sexual life. According to a retrospective follow-up study in central and eastern China, HPV clearance rate is closely related to age and virus duration. According to the observation, after 400 days of HPV infection, the self clearance rate decreased significantly. < / P > < p > according to research, every 5 years of age increases, the HPV clearance rate decreases by 15%. In other words, the longer the virus exists, the more difficult it is to remove it by itself. The older you get, the less likely you are to get rid of it through your own immunity. < p > < p > human papillomavirus (HPV) is a small double stranded DNA virus. At present, scientists have identified more than 200 types of HPV, including 12 high-risk types, which can cause cancer. < / P > < p > in addition to cervical cancer, it can also cause anal cancer, vulvar cancer, vaginal cancer, penile cancer and oral cancer. Therefore, HPV vaccination has positive significance for the prevention of these cancers. This is because the virus like particles used as vaccines only contain viral capsid protein L1 and have no viral nucleic acid structure, so they are not infectious. However, the virus like particles retain the immunogenicity of L1, which can induce immune response and produce protective neutralizing antibody.
we still use data to say that after the Chinese mainland women vaccinated, both the 2 valent vaccine or the 4 valent vaccine, including the domestic 2 valent vaccine, produced immunogenicity in 96%-100%. Of course, there are still some differences in the data of antibody production among different ages. The antibody level of women aged 9-14 was twice as high as that of women aged 18-26. After vaccination, the antibody level of women aged 9-17 was 2-3 times higher than that of women aged 18-25. The titer of QV HPV (tetravalent) vaccine was 1.4-2.8 times higher in 9-15 year-old men and women than in 16-26-year-old women. However, the immune responses to HPV6 / 11 / 16 / 18 in 9-15-year-old women and 16-26-year-old men were similar to those vaccinated with tetravalent HPV vaccine. < / P > < p > this problem is the same, we still need to take data to talk about the protective effect of line price vaccine (BV HPV) on Chinese women (18-25 years old). According to the data, HPV infection was reduced by 96.3% and 96.9% from 6 months to 12 months after vaccination. The protective effect of Cin2 / 3 or AIS was 87.3%. < / P > < p > in the same study, the protective effect of 4-valent vaccine (qv HPV) on uninfected women (20-45 years old) was reduced by 91.6% and 97.5% from 6 months to 12 months after vaccination, and the protective effect of prevention related Cin2 / 3 or a1s was 100%. < / P > < p > if the above pile of data makes your head big, then you can read the following sentence. According to different studies at home and abroad, no matter whether the price is 2 or 4 or 9, it has a strong protection effect. You can choose the type of vaccine according to your own situation. < / P > < p > the history of HPV vaccine is long or short. It has been 13 years since its birth. How many years can be protected after vaccination remains to be observed and summarized, and the time to verify its effect. However, according to the available data, there has been a 9.4-year follow-up study on imported bivalent vaccines in foreign countries, and no related disease has been found so far. However, no lesions were found during the follow-up of 12 years. It is not necessary to strengthen vaccination in the year. According to its current performance, HPV vaccines show immune persistence and long protective effect. Both Chinese research and who have told us that HPV vaccine is safe and effective, and the possible adverse reactions after vaccination are listed in the table below. We can choose to vaccinate before the holidays and have enough time to rest after vaccination. There is no need to worry too much if pregnancy is found after vaccination. According to the existing research and data, HPV vaccine has no great impact on the pregnant mother or infant, so it is only necessary to re vaccinate after the end of pregnancy. < / P > < p > for young women, we just need to be vaccinated, but for older women, vaccination and regular cervical cancer screening are needed to ensure that everything is safe and sound.